Senior Research Scientist – Protein Engineering and Novel Modalities

Locations: Cambridge, UKSalary & Benefits CompetitiveIntroduction to role:Are you ready to take a crucial inter-disciplinary approach to deliver life-changing medicines? We are seeking a highly motivated Senior Research Scientist to help support our Respiratory and Immunology discovery pipeline. The role will involve developing and implementing our next-generation modalities in their application to pre-clinical programs.Accountabilities:As a Senior Research Scientist, you will bring your expertise in multivalent molecular design to the table. Your experience in the application of protein, molecular biology and/or biophysical skill sets will be crucial in creating and characterising the next generation of biologics, with a focus on multi-specific molecules and cellular engagers. You will execute experiments efficiently, analyse, interpret, and present data and ideas to a wider audience.Essential Skills/Experience:Ph.D level scientist, or Batchelor’s degree with significant experience in an industry settingUnderstanding of antibody structure-function relationshipsExperience in protein design, production and characterisation of antibodies, or antibody-like scaffolds using common expression systems (e.g. mammalian) and purification methods (e.g. Akta systems), and the ability to profile constructs (e.g. SPR; biochemical assays)Strong hands-on experience in molecular biology methods and technologies e.g., PCR, RT-PCR, cloning (ligation-dependent and independent methods), site-directed mutagenesis, Sanger sequencing/analysisAbility to work independently, to optimize protocols, troubleshoot, interpret experimental results/data and maintain accurate, high quality and up-to-date experimental recordsStrong communication skills in a team environment and an ability to quickly learn and adopt new technologiesDesirable Skills/Experience:Background in drug discovery and development in the pharmaceutical industry or academiaStrong publication record, as evidenced by patents and/or publicationsExperience in silico design and optimisation of proteinsExperience in automationWhen we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. The role is primarily lab-based and requires you to be present on-site.Why AstraZeneca?We take an inter-disciplinary approach including novel biomarkers, AI, novel endpoints and cutting-edge trial designs to shape the future of our business and therapeutic areas. Our commitment to patients and pioneering spirit are truly embedded and it's what makes our pipeline unique. We foster a mindset of courage, where everyone is empowered to step up, innovate and work at pace. As part of our Respiratory & Immunology team in Biologics Engineering you will be at the forefront of applying novel modalities and using innovative approaches to create new possibilities.Ready to make a difference? Apply now and join us in our journey to push the boundaries of science to deliver life-changing medicines.So, what’s next?Complete your application before the below closing date.This role is open from 2/05/#####, we welcome your application no later than 17/05/2024Where can I find out more?Follow AstraZeneca on LinkedIn AstraZeneca on Facebook AstraZeneca on Instagram
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