Research And Development Scientist

Job Description
Job Title:
Senior/Research Scientist – Mass spec
Contract:
12 months
Location:
Slough
Salary:
£28.09 – 33.58 PAYE, £38.24 Umbrella
SRG are working with a Global Biopharmaceutical company to help them find a
Senior/Research Scientist
to join their busy team.
This is an exciting opportunity for an individual experienced in HDX-MS to join the Mass Spectrometry team within the Protein Structure and Biophysics Group.
Key Responsibilities will include:
and mechanistic understanding of target and therapeutic molecule interactions are driven by our department using Mass Spectrometry, Cryo-EM, X-ray crystallography, SAXS, NMR and other biophysical techniques.
track record in the design and execution of HDX-MS experiments with a contextual understanding of their results alongside other structural data.
and prioritise the demands from multiple projects.
Essential Requirements:
or BSc with 5+ years of relevant laboratory-based experience in the design, execution and analysis of HDX-MS experiments for
antibody/protein/ligand
interactions.
with Waters data processing software packages (PLGS) and DynamX™.
knowledge Waters HDX-MS system.
of structural visualisation tools (PyMOL, Chimera or similar).
with HDX-MS experiments using NBE and NCE molecules.
organisational, communication, record keeping and team-working abilities.
Desirable Requirements:
analysis of membrane proteins.
and maintenance of Waters LC/MS equipment.
ability with Native MS, ion mobility MS, SEC-MS or intact mass LC/MS.
track record of publications related to mass spectrometry in peer reviewed journals.
of recombinant protein expression systems and PTMs.
knowledge of Thermo Scientific Orbitrap MS systems.