Principal Scientist - Vaccine development

Job Description
Date posted: 11 March 2024
Closing Date: Applications will be considered on a rolling basis
Are you passionate about vaccine development and excited about the prospect of contributing to ground-breakingresearchin the field of vaccine discovery? Baseimmune, a cutting-edge biotechnology company based in London, is seeking a talentedPrincipal Scientist in Vaccine developmentto join our team.
Who we are
Baseimmune is a discovery stage biotech start-up focused on developing cross-protective vaccines through computationally designed antigens. Founded by the team that pioneered computational approaches to design vaccines against infectious diseases at the Jenner Institute University of Oxford. Our mission is to revolutionise vaccines design by harnessing the power of computational biology, data analytics, and machine learning to generate longer lasting and mutation-proof vaccines.
The role
We are seeking a highly motivated and experienced vaccine developer to join aninterdisciplinary team located at the London Bioscience Innovation Centre in King’s Cross, London.This is a full time, laboratory-based role.
As a principal scientist, you’ll be responsible for leading, management, and execution of discovery and pre-clinical programs of novel cross-protective vaccines. This includes the design and production of vaccines at lab scale, testing in animal models, and assessing their performance using state of the art immunological approaches to advance our pipeline.
Key Responsibilities:
Leading and managing vaccine development projects from discovery to preclinical development.
Designing and executing preclinical studies to assess novel vaccine candidates.
Regularly communicate and present results to leadership teams.
Manage external projects with CROs and external collaborators.
Maintain familiarity with scientific and technical literature pertinent to the projects.
Collaborating with cross-functional teams to integrate scientific insights into the development process.
Providing mentorship and guidance to junior team members.
Essential Qualifications and Skills
Minimum Ph.D. degree with post-doctoral experience in immunology and pre-clinical vaccine development.
Proven experience with a strong scientific publication record in vaccine development.
Experience with protein production usingin vitrosystems (mammalian/insect and bacterial) and protein purification (FPLC).
Experience with immune assays such as flow cytometry, ELISA, ELISpot, and neutralisation assays for evaluation of immune responses.
Strong analytical and problem-solving abilities.
Leadership skills with the ability to drive projects forward in a fast-paced startup environment.
Ability to work independently and within a collaborative research environment.
Comfortable with working with multiple projects.
Excellent organisational, record-keeping abilities, and oral and written communication skills.
Desired skills
Expertise in general molecular biology (cloning, PCR).
Experienced in protein production and purification with AKTA FPLC systems.
Understanding of the vaccine pre-clinical development process in a biotech environment.
What we offer
Competitive starting salary
Private medical health insurance
Opportunities for career growth
26 days holiday leave + bank holidays
Enhanced sick pay
Pension plan
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