Principal Scientist, QSP

OverviewCertara accelerates medicines using proprietary biosimulation software, technology and services to transform traditional drug discovery and development. Its clients include more than 2,000 biopharmaceutical companies, academic institutions and regulatory agencies across 62 countries.Certara is a growing company that provides a dynamic and exciting place to work. Our purpose is to assist in accelerating the development of meaningful medicines that make an impact on our society and the people that need them most. Innovation and creativity are highly valued, and everyone is given the opportunity for training and continuous development. Our portfolio spans the discovery, preclinical, clinical and post-marketing phases of drug development, working with 1,200 commercial companies, 250 academic institutions, and numerous regulatory agencies.The Certara Quantitative Systems Pharmacology (QSP) group is a global organization focused on the impactful application of QSP and mechanistic PKPD modeling and simulation in drug discovery and development. We are leading several first-of-its-kind QSP Consortia with more than 10 global pharmaceutical companies and have a rapidly expanding consultancy portfolio. Our QSP scientists work in close collaboration with other Certara staff and clients to generate and use state-of-the-art mechanistic models for decision making in pharmaceutical R&D. The models are designed in close dialogue with clients and developed with a view to creating user-friendly tools that will inform drug development programs from discovery to regulatory filing. We have unique capability to seamlessly integrate bespoke QSP models into the Simcyp physiologically based pharmacokinetic (PBPK) platform. Besides our well-established leadership in applied QSP approaches in Immunology and Immuno-Oncology, we are now also the leading provider of QSP approaches in neuro-degenerative diseases through Certara’s recent acquisition of the In Silico Biosciences modelling platform.We are seeking highly motivated and talented QSP modelling experts, who share our passion for using quantitative approaches to understand and impact complex drug discovery and development questions. Positions are available at various levels of experience across our global locations and for flexible, home-based roles. ResponsibilitiesProvide scientific and operational leadership for QSP consortia and/or consultancy projects, ensuring clients receive the expected impact in a timely mannerMentor, train and (if required) supervise QSP scientistsProvide hands-on technical and scientific support for QSP consultancy and consortia projectsAct as internal and external leader in at least one (emerging) QSP scientific and/or technology subject and liaise with other groups in the Simcyp Division and CertaraRepresent QSP in cross Simcyp Division and Certara initiativesLiaise with (potential) clients on existing and new projectsContribute to writing new project proposalsReview work from other QSP scientistsBe an active contributor to the external scientific community, present work at meetings and aim to publish work in peer-reviewed journalsLead-by-example and proactively help with the implementation and development of best practices in all scientific, operational and organizational areas of QSP QualificationsPhD (or equivalent) in life sciences, engineering, computer sciences, mathematics physics or equivalent.A minimum of 5 years of QSP industry/consulting experience.Excellent understanding of PKPD, QSP, and mathematical biology and its application in drug discovery and development.Very familiar and outstanding hands-on expertise with QSP modelling software.Excellent interpersonal skills; demonstrated ability to work effectively in a multi-disciplinary team on complex projects. Ability to work virtually with project teams across different locations and time zones.Ability to clearly and effectively communicate with all stakeholders. Excellent presentation and writing skills.Organised and with track record of delivering quality results on time.Ability to manage multiple client project timelines and deliverables simultaneously.Self-reliant.Good publication record.
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