Formulation Senior Scientist, Tumour Targeted Delivery, Oncology R&D

About AstraZenecaAstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the worlds most serious diseases. But were more than one of the worlds leading pharmaceutical companies.Site descriptionOur TTD-Chemistry site situated in Whitechapel, London is one of over 400 sites here at AstraZeneca, providing an environment where everyone feels comfortable and able to be themselves is at the core of AstraZenecas priorities, its important to us that you bring your full self to work every day. To help you maintain your best self, heres a sneak peek into some of the things this site provides for you After-work events, Lunch Learns, spacious balanced office working environment. Situated in the heart of Londons historical east end close to the fashionable areas of Shoreditch, Spitalfields and Brick Lane with excellent public transport links to central London.Business areaTake our leading Oncology pipeline to the next level! Working with one of the broadest and deepest Oncology pipelines in the industry offers the possibility to work on the most novel molecules at all development stages. It takes each of us challenging our thinking to keep pushing our pipeline forward and craft the future of Oncology. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. Thats why we work, on average, a minimum of three days per week from the office.What Youll DoAs a Formulation Senior Scientist, you will use your scientific judgement to develop colloidally and conformationally stable formulations of conjugated biologics.You will perform biophysical characterisation and associated stability studies, analyse and interpret experimental data, and contribute to decision making for early-stage drug discovery programmes.Essential For The RolePh.D in Chemistry, Biochemistry, Bio/Chemical engineering, Pharmaceutical Sciences or relevant disciplineM.Sc or B.Sc in above disciplines with relevant industrial experienceExperience with formulation strategies, purification, biophysical characterization and stability testing of proteins/conjugatesKnowledge of antibody and/or general protein sequence and structural analysisStrong background in chemistry and protein biochemistryHands on experience of performing a range of protein/bioconjugate characterisation by Dynamic Light Scattering (DLS), Differential Scanning Calorimetry (DSC), size-exclusion/hydrophobic interaction/ion exchange chromatography HPLC, cIEF, ceSDS, nephelometry, UV/Vis spectroscopy, and LCMSExperience with executing preparative chromatography purifications using AKTA and TFF systemsKnowledge and strong understanding of developing and optimising robust analytical methods for antibody drug conjugate/protein related conjugates characterisation might be beneficial.Please use the below link for job application and quicker response.
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